Correction of disorders of reparative processes after destructive methods of treatment of the cervix uteri
DOI:
https://doi.org/10.15574/HW.2025.5(180).58Keywords:
cervical pathology, reproductive age, destructive-pathological changes of the cervix, destructive-surgical treatment methods, autoplasmaAbstract
Destructive methods of treatment of the cervix uteri (CU), unfortunately, lead to destructive-pathological changes in its integumentary epithelium and, as a result, to a violation of the reproductive function of a woman, which requires differentiated treatment tactics.
Аim - to evaluate the effect of local application of autoplasma enriched with platelets on the regenerative ability of the CU epithelium after destructive methods of treatment of its pathology in women of reproductive age.
Materials and methods. 170 patients aged 18-45 years with cervical intraepithelial neoplasia were selected. All patients were previously examined. Subsequently, individual and differentiated etiopathogenetic treatment was performed. 56 (32.94%) patients underwent cryodestruction of the cervical canal, 70 (41.17%) patients underwent excision of the cervical canal and 44 (25.88%) underwent cone-shaped diathermoelectroconization (DEC) of CU. The patients were divided into two groups. The control group was treated according to standardized methods, and the main group was treated with local application of autoplasma enriched with platelets.
Results. After cryodestruction, no pathological conditions of the cervical canal were detected in the main group; in the control group, 19 women had cicatricial deformation of the cervical canal. After excision, cicatricial deformation of the cervical canal was observed in 11 women in the main group; in the control group: 27 women were diagnosed with cervical canal stenosis of the cervical canal, 1 woman had cervical canal atresia of the cervical canal, and the rest had cicatricial deformation of the cervical canal. After performing cone-shaped diathermoelectroconization in the main group, cicatricial deformation of the cervix was observed in 13 women; in the control group: cicatricial deformation of the cervix was observed in 8, stenosis of the cervical canal of the cervix in 9, and atresia of the canal of the cervix in 5.
Conclusions. After local application of autoplasma, the frequency of destructive-pathological changes in women included in the study significantly decreased.
The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution specified in the work. Informed consent of women was obtained for the study.
The authors declare the absence of a conflict of interest.
References
Britto AMA, Goes LR, Sivro A, Policarpo C, Meirelles ÂR, Furtado Y et al. (2020, Sep 3). HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection. Front Immunol. 11: 2078. https://doi.org/10.3389/fimmu.2020.02078; PMid:33013878 PMCid:PMC7494736
Burka OA, Lygyrda NF, Kutsovol VV, Svintsitska AV. (2021). The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them. Reproductive Endocrinology. 57: 61-67. https://doi.org/10.18370/2309-4117.2021.57.61-67
Gu L, Hong Z, Gao H, Qiu L, Di W. (2019). Incidence of cervical high-grade squamous intraepithelial lesions and squamous cell carcinoma in women with high-risk human papillomavirus and normal cervical cytology: A retrospective analysis of 1858 cases stratified by age and human papillomavirus genotype. Сytopathology. 30(I4): 419-425. https://doi.org/10.1111/cyt.12717; PMid:31069857
Katki HA, Schiffman M, Castle PE, Fetterman B, Poitras NE, Lorey T et al. (2013, Apr). Benchmarking CIN 3+ risk as the basis for incorporating HPV and Pap cotesting into cervical screening and management guidelines. J Low Genit Tract Dis. 17; 5 Suppl 1: S28-35. https://doi.org/10.1097/LGT.0b013e318285423c; PMid:23519302 PMCid:PMC3616419
Kindrativ EO, Henyk NI. (2021). Pathomorphology of cervical intraepithelial neoplasia in woman with infertility. World of Medicine and Biology. 2(76): 53-57. https://doi.org/10.26724/2079-8334-2021-2-76-53-57
Kostiuk IIu. (2020). Vahitnist i polohy u zhinok, yaki perenesly rizni metody likuvannia patolohii shyiky matky. Reproduktyvne zdorov'ia zhinky. 2: 35-39.
Kostiuk IIu. (2020). Vplyv khirurhichnykh metodiv likuvannia shyiky matky na reproduktyvnu funktsiiu zhinok. Reproduktyvne zdorov'ia zhinky. 4(44): 13-17.
Kurtay S, Ali KY, Hussein AI. (2022, Dec 7). Frequency of cervical premalignant lesions in the gynecologic patients of a tertiary hospital in Mogadishu, Somalia. BMC Womens Health. 22(1): 501. https://doi.org/10.1186/s12905-022-02106-0; PMid:36476212 PMCid:PMC9727848
Lewis RM, Laprise JF, Gargano JW, Unger ER, Querec TD, Chesson HW et al. (2021). Estimated Prevalence and Incidence of Disease-Associated Human Papillomavirus Types Among 15- to 59-Year-Olds in the United States. Sexually Transmitted Diseases. 48(I4): 273-277. https://doi.org/10.1097/OLQ.0000000000001356; PMid:33492097 PMCid:PMC10037549
Li X, Xiang F, Dai J, Zhang T, Chen Z, Zhang M et al. (2022, Sep 12). Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China. Virol J. 19(1): 146. https://doi.org/10.1186/s12985-022-01879-y; PMid:36096810 PMCid:PMC9465878
Massad LS, Einstein MH, Huh WK, Katki HA, Kinney WK, Schiffman M et al. (2013, Apr). 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet Gynecol. 121(4): 829-846. https://doi.org/10.1097/AOG.0b013e3182883a34; PMid:23635684
Mello V, Sundstrom RK. (2023). Cervical Intraepithelial Neoplasia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. URL: https://www.ncbi.nlm.nih.gov/books/NBK544371/.
MOZ Ukrainy. (2024). Pro zatverdzhennia Standartu medychnoi dopomohy «Skryninh raku shyiky matky. Vedennia patsiientok z anomalnymy rezultatamy skryninhu ta peredrakovymy stanamy shyiky matky». Nakaz MOZ Ukrainy vid 18.06.2024 No. 1057.
Plisko O, Zodzika J, Jermakova I, Rezeberga D, Kroica J, Liepniece-Karele I et al. (2022). Association between vaginal microflora, high-risk hpv infection and hpv e6/e7 expression in high grade cervical intraepithelial neoplasia. Journal of Obstetrics, Gynecology and Reproductive Biology. 270: 31. https://doi.org/10.1016/j.ejogrb.2021.11.128
Ren WH, Zhao XL, Zhao FH. (2021, Jun 24). Global guidelines for cervical cancer screening: a systematic review. Zhonghua Yi Xue Za Zhi. 101: 1882-1889. Epub ahead of print. doi: 10.3760/cma.j.cn112137-20210115-00134. PMID: 34192846.
Segal TR, Giudice LC. (2019, Oct). Before the beginning: environmental exposures and reproductive and obstetrical outcomes. Fertil Steril. 112(4): 613-621. https://doi.org/10.1016/j.fertnstert.2019.08.001; PMid:31561863
Tidy JA, Lyon R, Ellis K, Macdonald M, Palmer JE. (2020, Sep). The impact of age and high-risk human papillomavirus (hrHPV) status on the prevalence of high-grade cervical intraepithelial neoplasia (CIN2+) in women with persistent hrHPV-positive, cytology-negative screening samples: a prospective cohort study. BJOG. 127(10): 1260-1267. Epub 2020 May 3. https://doi.org/10.1111/1471-0528.16250; PMid:32279427
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ukrainian Journal Health of Woman
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC).
Authors transfer the copyright to the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.
