http://ujhw.med-expert.com.ua/issue/feed Ukrainian Journal «Health of Woman» 2026-04-18T07:55:10+03:00 Irina Sheiko pediatr@med-expert.com.ua Open Journal Systems <p>ISSN 2786-6017 (Online)<br />ISSN 2786-6009 (Print)</p> <p><strong><em>Title proper</em></strong><strong>:</strong> Український журнал Здоров'я жінки<br /><strong><em>Parallel title:</em></strong> Ukrainian journal Health of woman</p> <p><strong>History<br />The journal has been published since December 2003 <br /></strong>and is known as Health of woman to issue No. 1(157) 2021<br /><em>Title proper</em>: Здоровье женщины<br /><em>Parallel title:</em> Health of woman<br /><em>Parallel title:</em> Здоров'я жінки<br />ISSN 2307-5074 (Online) <br />ISSN 1992-5921 (Print)</p> <p><strong>Ukrainian journal Health of woman </strong>-is a peer-reviewed open access medical journal</p> <p><strong>Founders</strong><br />State Institution «Ukrainian center of maternity and childhood of the National Academy of Medical Sciences of Ukraine», Kyev, Ukraine<br />Bogomolets National Medical University, Kyiv, Ukraine<br />Citizen of Ukraine Bakhtiyarova D.O., Kyiv, Ukraine</p> <p><strong>Publisher</strong><strong>: </strong>Group of Companies Med Expert, LLC, Kyev, Ukraine</p> <p><strong>Frequency</strong><strong>: </strong>6 issues a year</p> <p><strong>Language</strong>: Ukrainian, English</p> <p><strong>Registration in the Ministry of Education and Science of Ukraine:</strong> has been included in the Higher Attestation Commission of Ukraine list <strong>(category B)</strong> as a specialized scientific edition for publication of the original research results by authors prior to be awarded the advanced academic degrees (PhD, Doctor of Medicine) according to the Ministry of Education and Science Resolution 08.06.2022 No. 530 </p> <p><strong>Indexing/abstracting:</strong><br />- Scientific Periodicals of Ukraine <br />- Bibliometrics of Ukrainian Science (the Vernadsky National Library)<br />- WorldCat<br />- Ulrich’s Periodicals Director<br />- CrossRef (Cited-by-linking)<br />- Google Scholar <br />- System abstracting Ukrainian scientific literature "Dzherelo"</p> <p><strong>Archive </strong>of the journal from Issue No.1(157) 2021 are publicly available at the <a href="http://ujhw.med-expert.com.ua/issue/archive">http://ujhw.med-expert.com.ua/issue/archive/</a> <br />- of the journal from 2010 to Issue 9-10(156) 2020 are publicly available at the: <a href="http://hw.med-expert.com.ua/issue/archive">http://hw.med-expert.com.ua/issue/archive</a></p> <p><strong>Contacts</strong><br /><em>Address for correspondence:</em> 04211, Ukraine, Kyiv, Academician Phylatov street, 2/1, office 18, Ukrainian journal Health of woman<br /><em>Tel/fax:</em> +38 044 498 0834; +38 044 498 0880<br /><em>Е-mail:</em> <a href="mailto:pediatr@med-expert.com.ua">pediatr@med-expert.com.ua</a>; <a href="mailto:seminar@med-expert.com.ua">seminar@med-expert.com.ua</a> <br /><em>website:</em> <a href="http://www.med-expert.com.ua">http://www.med-expert.com.ua</a></p> http://ujhw.med-expert.com.ua/article/view/357925 Anthropometric components of somatotype (endomorphy, mesomorphy, and ectomorphy) according to the Heath-Carter method and body composition components by the Matiegka method in women with infertility 2026-04-18T06:46:31+03:00 O.O. Berestovyy Berestovyyoo2@ukr.net A.R. Sizonenko Sizonenkoar2@ukr.net <p>&nbsp;Infertility in women of advanced reproductive age represents an important clinical and demographic challenge. Female reproductive potential declines significantly after the age of 35 due to progressive ovarian aging, reduced ovarian reserve, and increasing chromosomal abnormalities in oocytes. Consequently, infertility becomes more common, and reproductive outcomes are increasingly influenced by metabolic status, endocrine regulation, and overall systemic health.</p> <p><strong>Aim</strong> - to synthesize current evidence on the relationship between body composition, fat distribution, and reproductive outcomes in women of advanced reproductive age, with particular emphasis on the role of metabolic and endocrine factors.</p> <p>Special attention is given to the interaction between constitutional body morphology (somatotype), body composition parameters, and fertility, including outcomes of assisted reproductive technologies. In addition, existing gaps in the literature regarding the combined assessment of somatotype according to the Heath-Carter method and body composition based on the Matiegka approach in relation to female infertility are identified. Limited data on the interaction between these constitutional characteristics and stress-related adaptive responses are assessed, particularly under conditions of prolonged psychosocial stress. A conceptual framework integrating somatotype, body composition, metabolic regulation, and adaptive mechanisms in the context of female reproductive function is developed, and the need for further research, especially in populations exposed to chronic stress conditions such as those observed in Ukraine, is substantiated.</p> <p><strong>Conclusion. </strong>Such investigations, especially when conducted in populations exposed to prolonged war-related stress, may provide new insights into the constitutional and adaptive determinants of female reproductive function and contribute to the development of more personalized diagnostic and therapeutic strategies for infertility.</p> <p>The authors declare no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357885 Age structure of tuberculosis incidence among the female population of Ukraine in 2019-2023 2026-04-17T18:36:58+03:00 O.V. Feger Fegerov2@ukr.net R.Y. Pohoriliak Pohoriliakry2@ukr.net L.Y. Markovtsii Markovtsiily2@ukr.net V.V. Kalii Kaliivv2@ukr.net O.M. Kozar Kozarom2@ukr.net <p>Tuberculosis remains a leading infectious disease and a significant medical and social problem for the public health system of Ukraine. It is important to monitor the morbidity among women, because the age structure reflects the epidemic process, socio-economic factors and the effectiveness of anti-tuberculosis measures.</p> <p><strong>Aim</strong> <strong>- </strong>to analyze the dynamics and age structure of tuberculosis incidence among the female population of Ukraine in 2019-2023.</p> <p><strong>Materials and methods.</strong> A retrospective descriptive epidemiological study was conducted based on official statistical data of the Public Health Center of the Ministry of Health of Ukraine regarding the number of registered cases of tuberculosis among women in Ukraine in 2019-2023. The absolute indicators and their share in the overall structure of morbidity were analyzed. A comparative analysis of the dynamics by years and age groups was carried out with the determination of trends and structural changes. Methods of descriptive statistics, structural and comparative analysis were used.</p> <p><strong>The results.</strong> During 2019-2023, 27,833 cases of tuberculosis among the female population were registered in Ukraine. A decrease in the total number of cases was established from 7,529 in 2019 to 4,744 in 2022 (-36.9%), with a further increase to 5,057 in 2023. The incidence structure was dominated by women aged 35-44 (26.3% of the total number of cases). The age groups 45-54 years and 25-34 years also accounted for a significant share. A trend towards an increase in the specific weight of women aged 65 and older was revealed - from 11.8% in 2019 to 16.7% in 2023.The share of children and adolescents (0-17 years old) remained relatively low (about 6%), but in 2023 there was a certain increase in indicators in the age groups 5-14 years old.</p> <p><strong>Conclusions.</strong> In 2019-2023, Ukraine observed a general decrease in the registered incidence of tuberculosis among women with a minimum level in 2022 and a partial recovery in 2023. A shift in the age structure towards older age groups has been established. The decrease in indicators in 2020-2022 requires careful interpretation, taking into account the impact of the COVID-19 pandemic and military events on the completeness of detection and registration of cases.</p> <p>The authors declare no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357887 Analysis of sexual function in women with an implanted mid-urethral sling 2026-04-17T19:24:00+03:00 M.I. Kravtsiv Kravtsivmi2@ukr.net K.I. Bohadelnikova Bohadelnikovaki2@ukr.net K.V. Chaika Chaikakv2@ukr.net O.A. Taran Taranoa2@ukr.net H.O. Ivanova Ivanovaho2@ukr.net O.V. Sergiychuk Sergiychukov2@ukr.net S.O. Kachula Kachulaso2@ukr.net <p>Stress urinary incontinence negatively affects quality of life, social activity, and sexual health in women. In this context, the improvement of sexual function is a crucial indicator of treatment efficacy for urinary incontinence in this patient population.</p> <p><strong>Aim</strong> - to analyze sexual function as a key component of the clinical effectiveness of sling surgery in women with stress urinary incontinence.</p> <p><strong>Materials and methods.</strong> A comparative study of sexual function after sling surgical procedures for the correction of stress urinary incontinence was conducted in women under 50 years of age in two representative subgroups: IA (n=28) underwent free synthetic sling placement (TVT), and IB (n=30) underwent TVT-O combined with postoperative vaginal laser therapy. Women aged 50 and older were also divided into two subgroups: IIA (n=14) underwent TVT; IIB (n=10) underwent TVT-O followed by a postoperative course of promestriene (natural and semi-synthetic estrogens). Statistical analysis was performed using the SPSS 21 software package.</p> <p><strong>Results</strong>. Vaginal laser therapy after TVT-O sling implantation significantly improved sexual function in a greater number of patients under 50 years of age compared to the corresponding comparison group. Vaginal promestriene therapy after TVT-O did not significantly affect the quality of sexual life in women aged 50 and older.</p> <p><strong>Conclusions.</strong> Sexual function is an important component in evaluating the effectiveness of sling surgical intervention in women with stress urinary incontinence. Differentiated assessment of clinical manifestations of sexual dysfunction using specialized questionnaires allows identification of potential directions for their correction during further treatment.</p> <p>The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. Informed consent was obtained from all patients.</p> <p>The authors declare no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357892 Cervical cancer in a global context: a comparative assessment of the burden of disease and survival in countries with different income levels (2014-2024) 2026-04-17T20:07:30+03:00 Zh.A. Chornenka Chornenkazha2@ukr.net A.S. Biduchak Biduchakas2@ukr.net K.I. Yakovets Yakovetski2@ukr.net M.V. Dikal Dikalmv2@ukr.net E.Ts. Yasinska Yasinskaets2@ukr.net <p>Cervical cancer remains a major public health issue with significant disparities across countries of different income levels. In Ukraine, high morbidity and mortality persist, largely due to late diagnosis. Globally, over 85% of deaths occur in low- and middle-income countries, whereas high-income countries demonstrate declining rates due to effective vaccination against human papillomavirus (HPV) and screening programs.</p> <p><strong>Aim</strong> - to analyse the dynamics of morbidity, mortality, and 5-year survival of cervical cancer across countries with different income levels during 2014–2024 and assess prospects for elimination.</p> <p><strong>Materials and methods.</strong> A retrospective analysis of age-standardized rates (ASR) of incidence, mortality, and 5-year survival for cervical cancer (International Classification of Diseases, 10th Revision (ICD-10): C53) was conducted in 31 countries. Data were obtained from Global Cancer Observatory (GLOBOCAN), International Agency for Research on Cancer (IARC), World Health Organization (WHO), and national cancer registries. Countries were classified according to World Bank criteria. Absolute changes (Δ), intergroup comparisons, and trend analyses were performed.</p> <p><strong>Results.</strong> A clear association between socio-economic level and cervical cancer burden was identified. High-income countries showed a steady decline in incidence and mortality with high 5-year survival (70–80%), particularly in the United Kingdom, France, and Japan. Upper-middle-income countries demonstrated heterogeneous trends, with improvements in Central and Eastern Europe but increases in some Asian countries. Lower-middle-income countries showed predominantly negative trends, with rising incidence and mortality and minimal survival gains, with the highest burden in Sudan and Ghana. Low-income countries had the most unfavourable outcomes, with the highest incidence and mortality and low survival (33–43%), especially in Malawi and Uganda.</p> <p><strong>Conclusion.</strong> Cervical cancer burden is strongly associated with national income level. While elimination is achievable in high-income countries, low-income settings require intensified global support and accelerated implementation of the WHO “90-70-90” strategy.</p> <p>No conflict of interests was declared by the authors.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357893 The impact of psychosocial factors on menstrual function disorders in adolescent girls under conditions of military conflict 2026-04-17T20:31:55+03:00 A.V. Olshanska Olshanskaav2@ukr.net <p>Military actions create conditions of chronic stress that negatively impact the reproductive health of adolescents. The role of psychosocial isolation and emotional state in the development of menstrual dysfunction under the conditions of prolonged military conflict requires detailed study.</p> <p><strong>Aim</strong> - to evaluate the impact of psychosocial factors and stress levels on menstrual cycle regularity in adolescent girls during military conflict.</p> <p><strong>Materials and methods.</strong> A survey was conducted among 100 girls (aged 11–18 years). Two groups were formed based on the regularity of the menstrual cycle: the main group (n=28) - girls with menstrual cycle disorders; and the comparison group (n=72) - girls with a regular cycle. Stress susceptibility was assessed using the "Determination of the degree of susceptibility to stress" questionnaire (adapted by M.M. Prylyutska). Statistical analysis was performed by calculating relative values; Student's t-test and p-value were used to assess the significance of differences.</p> <p><strong>Results.</strong> It was established that the key social risk factor is the restriction of in-person (offline) learning. The obtained data confirm that social isolation and the transition to distance learning under martial law significantly impair the adaptive capacities of adolescents, which correlates with menstrual cycle disorders. A comparative analysis of the psycho-emotional state revealed that a high level of exhaustion occurred significantly more frequently in the girls of the main group. Pronounced psycho-emotional exhaustion under chronic wartime stress is a powerful predictor of menstrual dysfunction in adolescent girls.</p> <p><strong>Conclusions.</strong> The lack of socialization ("social vacuum") and a high level of stress load under the conditions of military conflict are determinants of menstrual dysfunction. Almost two-thirds of the respondents with an irregular menstrual cycle significantly more often had pronounced psycho-emotional exhaustion, adaptation difficulties, and a high level of emotional distress. The most common manifestations were feelings of fatigue, lack of recovery after rest, and anxiety without an apparent cause.</p> <p>No conflict of interests was declared by the author.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357895 The effect of preventive therapy for placental dysfunction on uteroplacental blood flow in pregnant women with low-lying placenta 2026-04-17T20:58:31+03:00 S.V. Pecheriaha Pecheriahasv2@ukr.net <p>The mother's health and the quality of placental formation in early pregnancy determine the course of gestation, fetal development, and neonatal prognosis. One of the key disorders that negatively affects these processes is placental dysfunction, in the development of which low chorionic attachment plays a special role, disrupting implantation and vascularization of the placenta.</p> <p><strong>Aim</strong> - to evaluate the effectiveness of a complex of preventive measures for the formation of uteroplacental blood flow in pregnant women with low chorionic localization in early pregnancy.</p> <p><strong>Materials and methods.</strong> A total of 119 pregnant women were observed: 64 patients received preventive therapy (micronized progesterone, ginkgo biloba, folic acid, and magnesium) from early gestation and 55 patients were in the control group without preventive intervention. Doppler parameters of the right and left uterine arteries and spiral arteries were evaluated, as well as the morphofunctional characteristics of the chorion using three-dimensional VOCAL technology (chorion volume, vascularization index).</p> <p><strong>Results. </strong>In patients of the main group, there was a significant decrease in resistance indices in the uterine and spiral arteries, an increase in diastolic and mean blood flow velocities by 30-40%, an increase in chorionic volume (62.0±4.1 cm<sup>3</sup> vs. 48.1±3.8 cm<sup>3</sup>) and its vascularization (vascularization index - 17.8±0.38 vs. 9.68±0.12) compared to the control group. The data indicate an improvement in the hemodynamics of the “mother-placenta-fetus” system and more effective formation of the fetoplacental complex.</p> <p><strong>Conclusions. </strong>Early application of the proposed complex of preventive measures in pregnant women with low-lying placenta contributes to the normalization of uteroplacental blood flow, improves chorionic vascularization, and reduces the risk of developing primary placental dysfunction, which provides favorable conditions for fetal development.</p> <p>The study was performed in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from all patients.</p> <p>The author declares no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357897 The state of uteroplacental hemodynamics in women giving birth for the first time, of different reproductive ages 2026-04-17T21:10:27+03:00 А.V. Chernov Chernovav2@ukr.net <p><strong>Aim </strong>- to analyze the state of uteroplacental hemodynamics and hormonal function of the fetoplacental complex in women giving birth for the first time, of different reproductive ages to optimize corrective therapy and promote timely delivery.</p> <p><strong>Materials and methods.</strong>. 174 histories of pregnancy and childbirth of women giving birth for the first time were analyzed, which were divided into groups according to age: I group - 85 pregnant women aged 20-29 years, II group - 89 pregnant women aged 30-40 years. The indicators of blood flow parameters in the "mother-placenta-fetus" system, the content of hormones: progesterone, placental lactogen, estriol were studied. Statistical processing of the research results was carried out using standard programs "Microsoft Excel 7.0" and "Statistica 8.0".</p> <p><strong>Results. </strong>Resistance indicators in the uteroplacental and fetal-placental blood flow links in group II showed a significant decrease in blood flow as pregnancy progresses, in the umbilical artery from 33 weeks of gestation (p&lt;0.001). At 18-27 weeks in group II pregnant women, blood flow disorders in the mother-placenta-fetus system were detected in 14 (15.7%) cases, and by 37 weeks their number increased significantly and amounted to 22 (24.7%) cases. In every fifth woman in group II in the II and III trimesters, the progesterone level was 2 times lower than normal. A significant decrease in estriol concentrations was observed in pregnant women in group II: in the II trimester in every fourth woman - 23 (25.8%) cases, and in the III trimester in almost <sup>2</sup>/<sub>3</sub> cases in 53 (59.6%) pregnant women. Similar patterns were found when studying the content of placental lactogen.</p> <p><strong>Conclusions.</strong> Dynamic monitoring of pregnant women over 30 years old who are giving birth for the first time, with mandatory ultrasound dopplerometry, allows for timely detection of circulatory disorders in the mother-placenta-fetus system and early signs of placental insufficiency and timely correction of these disorders and timely delivery.</p> <p>The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the paper. The informed consent of the patients was obtained for conducting the studies.</p> <p>No conflict of interests was declared by the author.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357899 Analysis of the clinical efficacy of pathogenetically justified secondary prevention of early reproductive losses in women with РАІ-1 gene polymorphism 2026-04-17T21:24:18+03:00 Yu.M. Duka Dukayum2@ukr.net V.V. Panov Panovvv2@ukr.net <p><strong>Aim </strong>- to analyse the clinical efficacy of a pathogenetically justified method of secondary prevention of early reproductive losses in women with <em>РA</em><em>І-</em><em>1</em> gene polymorphism.</p> <p><strong>Materials and methods. </strong>The selected patients (n=115) were divided into three groups according to their genotype: Group I (n=20) - patients with the wild-type 675 5G&gt;5G genotype of the <em>PAI-1</em> gene; Group II (n=53) - women with the heterozygous 675 5G&gt;4G polymorphism; Group III (n=42) - women with the homozygous 675 4G&gt;4G polymorphism. Based on the study results and identified associative links, a method for secondary prevention of early reproductive losses was developed to reduce the manifestations and impact of endothelial dysfunction.</p> <p><strong>Results. </strong>The average age of women in the thematic groups was comparable and amounted to 32,5±0,9, 33,9±0,7 and 33,6±0,7 years, respectively. Correlation analysis revealed significant associations between hemostatic parameters, lipid metabolism, immunological factors, and pregnancy loss, depending on the PAI-1 gene polymorphism type. It was demonstrated that early pregnancy loss results from a complex interaction of genetic, metabolic, immune, and hemostatic factors.</p> <p><strong>Conclusions. </strong>Timely correction of endothelial dysfunction manifestations at the pre-pregnancy stage with a combination of sulodexide and ezetimibe appears to be a promising approach in terms of minimizing pregnancy complications due to their ability to restore the endothelium and promote normalization of <em>PAI-1</em> production at the level of its genotype transcription.</p> <p>The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies.</p> <p>No conflict of interests was declared by the authors.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357902 Experimental justification of the use of enterosorption detoxification in pregnant women with diseases of the hepatobiliary system 2026-04-17T21:39:57+03:00 A.B. Рrуlutska Рrуlutskaab2@ukr.net L.I. Martynova Martynovali2@ukr.net V.S. Ostashevska Ostashevskavs2@ukr.net D.О. Govsіeіev Govsіeіevod2@ukr.net <p><strong>Аim -</strong> to evaluate and compare the sorption properties of carbon and chitin enterosorbents with respect to bile components under experimental conditions.</p> <p><strong>Materials and methods</strong>. The work used experimental studies of bile from 56 pregnant women with diseases of the hepatobiliary system, where the sorption capacity of carbon and chitin sorbents in relation to bile acids, cholesterol, bilirubin was studied. The sorption value of carbon and chitin sorbents was studied depending on the corresponding concentration of bile acids and bilirubin - with subsequent statistical processing of the results obtained</p> <p><strong>Results.</strong> Analysis of the results of the conducted studies showed the presence of sorption and detoxification properties of both carbon sorbents and chitin sorbents for bilirubin, bile acids, cholesterol, which coincides with the literature data. It should be noted that under experimental conditions, when diluting bile, the sorption efficiency increased in both sorbents, which indicates the peculiarities of the interaction of sorbents in more concentrated environments. Regardless of the experimental conditions, chitin sorbents demonstrated higher rates of bile acid adsorption. A similar trend was observed for cholesterol. As for bilirubin, the difference was less pronounced, but remained statistically significant. The presence of greater sorption properties in the chitin sorbent is probably associated with its chemical structure and ability to electrostatic interactions.</p> <p><strong>Conclusions.</strong> Based on experimental research, it was determined that both carbon sorbents and chitin sorbents have sorption and detoxification properties for bile components, but the sorption efficiency of the chitin sorbent was superior to that of the carbon sorbent, probably due to its chemical structure and ability to electrostatic interactions..</p> <p>The authors declare no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357908 Obstetric aspects and perinatal outcomes of pregnancy management and delivery in women with placenta previa and abnormally invasive placenta: own experience 2026-04-17T22:29:46+03:00 N.V. Herevych Herevychnv2@ukr.net Ye.O. Koloturska Koloturskayeo2@ukr.netm Yu.A. Batman Batmanyua2@ukr.net D.O. Govsieiev Govsieievdo2@ukr.net <p>Placenta previa (PP) and placenta accreta spectrum (PAS) are associated with a high risk of major obstetric hemorrhage, preterm delivery, and impaired early neonatal adaptation. Data on the structure of neonatal morbidity in such pregnancies remain limited in Ukrainian tertiary care centers.</p> <p><strong>Aim</strong> - to identify the spectrum of neonatal abnormalities and transient pathological conditions in infants born from pregnancies complicated by PP and/or PAS in order to optimize neonatal care.</p> <p><strong>Materials and methods.</strong> This retrospective cohort study included 115 pregnancies complicated by PP and/or PAS that ended in planned or emergency cesarean delivery in 2020-2024. Eighty-five cases of PP and 30 cases of PAS were analyzed. Clinical and anamnestic data, intraoperative characteristics, placental pathomorphology, gestational age and birth weight, rates of admission to the neonatal intensive care unit (NICU), and neonatal morbidity patterns were assessed.</p> <p><strong>Results.</strong> PP and/or PAS were associated with increased rates of preterm birth, major obstetric hemorrhage, and impaired neonatal adaptation. In the PAS group, blood loss exceeded 1000 mL in 93% of cases, and the mean operative time was longer than in the PP group. Overall, 42 (36.5%) newborns required NICU admission; the leading indications were respiratory distress syndrome, other respiratory disorders, and transient tachypnea. Among 73 infants transferred to rooming-in care 27 (36.9%) developed transient adaptation disorders. In 2023-2024, the proportion of infants born before 28 weeks of gestation increased.</p> <p><strong>Conclusions.</strong> PP and PAS define a high-risk perinatal group due to the combination of prematurity, obstetric hemorrhage, and neonatal respiratory morbidity. Cesarean delivery at 37 weeks was not associated with severe neonatal pathology but was accompanied by maladaptation disorders, which requires readiness for early respiratory support and close neonatal monitoring.</p> <p>The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Bioethics and Deontology Committee of the institution specified in this paper. Written informed consent was obtained from all participants prior to inclusion in the study.</p> <p>The authors declare no conflict of interest.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357912 Farewell and burial experience following perinatal loss: psychological adaptation of women 2026-04-17T22:51:34+03:00 T.O. But Butto2@ukr.net I.O. Frankova Frankovaio2@ukr.net I.V. Leshchuk Leshchukiv2@ukr.net <p>Perinatal loss is a significant psychologically traumatic experience associated with an increased risk of prolonged grief disorder, post-traumatic stress disorder, and somatic distress. The role of farewell and burial experience in the process of psychological adaptation remains insufficiently studied. In the context of forced displacement in Ukraine, access to a complete farewell and regular visits to the burial site may be limited, potentially affecting the integration of loss.</p> <p><strong>Aim - </strong>to determine the relationship between components of farewell and burial experience and indicators of psychological adaptation in women following perinatal loss.</p> <p><strong>Materials and methods. </strong>A cross-sectional online study was conducted involving 67 women who had experienced perinatal loss. Grief intensity, post-traumatic symptoms, anxiety-depressive distress, somatic symptoms, avoidance, negative cognitions, relationship satisfaction, and coping efficacy were assessed using validated psychometric instruments. Non-parametric group comparison methods and correlation analysis were applied. The level of statistical significance was set at p&lt;0.05.</p> <p><strong>Results. </strong>The ability to perform a burial ritual to the desired extent was associated with higher relationship satisfaction (p=0.003) and greater coping efficacy (p=0.014). The presence of a burial site was associated with higher coping efficacy (p=0.033), while only a trend toward higher relationship satisfaction was observed (p=0.063). Barriers to visiting the burial site were associated with higher post-traumatic stress symptoms (p=0.008) and lower relationship satisfaction (p=0.001). Physical contact with the infant’s body did not demonstrate statistically significant relationships with mental health outcomes.</p> <p><strong>Conclusions. </strong>A more complete farewell and burial experience following perinatal loss is associated with better adaptive outcomes, particularly greater coping efficacy. A trend toward higher relationship satisfaction was also observed. In contrast, barriers to visiting the burial site are associated with more pronounced post-traumatic stress symptoms and lower interpersonal relationship satisfaction.</p> <p>No conflict of interests was declared by the authors.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357929 A modern view of preeclampsia: pathogenesis, prognosis, prevention, diagnosis and treatment (clinical lecture with test tasks) 2026-04-18T07:55:10+03:00 T.G. Romanenko Romanenkotg@ukr.net O.V. Morozova Morozovaov2@ukr.net L.Y. Staselovych Staselovychlv2@ukr.net H.M. Zhaloba Zhalobahm2@ukr.net O.P. Kononets Kononetsop2@ukr.net <p><strong>Aim </strong>- to increase the effectiveness of prediction, prevention, diagnosis and treatment of preeclampsia (PE) according to the obtained modern literature data, thereby reducing the frequency of obstetric and perinatal complications.</p> <p>Presented are modern data on the etiology, pathogenesis, prediction and prevention of PE according to the recommendations of domestic and foreign protocols, as well as data from the statistical department of the Ministry of Health of Ukraine for the last 10 years from 2012 to 2022, which demonstrate an increase in the frequency of hypertensive disorders during pregnancy, against the background of a decrease in the specific gravity of PE and eclampsia. In 2022-2023, during the war years, a significant increase in the frequency of development of both hypertensive disorders and PE is noted. Data are provided on risk factors for the development of hypertensive disorders during pregnancy, the formation of risk groups, the appointment of modern preventive methods to reduce the frequency and severity of the development of PE. The modern classification of hypertensive disorders during pregnancy and PE is considered. Clinical cases of the course of PE, PE phenotypes and their treatment tactics are presented. The terms and methods of delivery in early and late PE are carefully described.</p> <p><strong>Conclusions.</strong> The management of pregnant women with PE remains a difficult task, requiring modern efforts of obstetrician-gynecologists, including the implementation of new methods of prediction, prevention, diagnosis and treatment of PE, preparation and management of childbirth in these patients.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357926 Neoadjuvant combined systemic chemotherapy in the treatment of advanced epithelial ovarian cancer: clinical experience 2026-04-18T07:03:35+03:00 R.M. Banakhevych Banakhevychrm2@ukr.net V.A. Shamrai Shamraiva2@ukr.net N.V. Tytarenko Tytarenkonv2@ukr.net V.O. Rud Rudvo2@ukr.et O.V. Bodnarchuk Bodnarchukov2@ukr.net G.V. Bevz Bevzgv2@ukr.net P.P. Slobodian Slobodianpp2@ukr.net <p>Ovarian cancer ranks second or third among the most common gynecologic malignancies in many countries and is associated with a high mortality rate. The main method of treating this pathology is a combination of cytoreductive surgery and systemic chemotherapy, which is administered in either the neoadjuvant or adjuvant setting depending on the specific clinical situation. In cases of tumor unresectability, carcinomatosis, or the presence of concomitant diseases, neoadjuvant chemotherapy is increasingly used, with the aim of increasing the likelihood of complete tumor resection during cytoreductive surgery. Attempts to identify subgroups of patients who are likely to benefit from neoadjuvant chemotherapy remain the subject of active scientific research.</p> <p><strong>Aim</strong> - to describe and analyze the results of combined neoadjuvant chemotherapy with aflibercept in the treatment of advanced epithelial ovarian cancer to increase doctors' awareness of this pathology.</p> <p><strong>Clinical case.</strong> A clinical case is presented involving the treatment of a 65-year-old patient with poorly differentiated serous ovarian adenocarcinoma, peritoneal dissemination, ascites, and high tumor burden (FIGO IIIC, pT3N0M0) (PCI 31). A distinctive feature of this case was the administration of six cycles of neoadjuvant combination systemic chemotherapy, which made it possible to achieve a marked partial response, followed by complete cytoreductive surgery and positive dynamics of tumor markers CA-125, HE4, and ROMA. The role of aflibercept in the treatment of epithelial ovarian carcinoma is also discussed.</p> <p><strong>Conclusions.</strong> Epithelial ovarian cancer is one of the most common pathologies in terms of incidence and mortality in modern gynecologic oncology practice. Approximately 75% of cases are diagnosed at advanced stages of the disease, when the possibility of complete resectability is debatable.</p> <p>In cases of tumor unresectability and/or the inability to achieve complete cytoreduction, a promising approach is to supplement standard neoadjuvant chemotherapy with an angiogenesis inhibitor (aflibercept), which can increase the likelihood of complete resection of the neoplasm during cytoreductive surgery, accompanied by a positive trend in tumor markers.</p> <p>Written informed consent for treatment and publication of this case was obtained from the patient.</p> <p>No conflict of interests was declared by the authors.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman http://ujhw.med-expert.com.ua/article/view/357927 The role of multiparametric ultrasonography in verifying the status of mesh implants after surgical treatment of genital prolapse 2026-04-18T07:36:45+03:00 V.P. Bondaruk Bondarukvp2@ukr.net O.O. Karlova Karlovaoo2@ukr.net M.M. Kryvoruk Kryvorukmm2@ukr.net <p>Genital prolapse (GP) remains a common pathology that significantly impairs the quality of life in women. Among modern surgical methods for correcting apical descent, laparoscopic sacrocolpopexy (SCP) and laparoscopic pectopexy (PP) hold leading positions. SCP is associated with certain risks, including damage to presacral vessels, chronic constipation, and osteomyelitis. Pectopexy serves as an innovative alternative involving the fixation of a mesh implant to the iliopectineal (pectineal) ligaments. This approach avoids the critical areas of the promontory and reduces the frequency of complications. Objective assessment of the mesh implant’s condition post-surgery using the traditional POP-Q clinical examination is limited, as it does not provide data regarding the position, integrity, tension, or interaction of the prosthesis with surrounding tissues. In this context, multiparametric ultrasonography (transperineal ultrasound with 3D/4D reconstruction) becomes crucial as a real-time imaging method, particularly during the Valsalva maneuver.</p> <p><strong>Aim -</strong> вased on clinical case analysis, to determine key ultrasound features of mesh implant positioning following reconstructive surgery for pelvic organ prolapse.</p> <p>Based on the analysis of original clinical observations, key ultrasound criteria for the normal state of a mesh implant after laparoscopic PP were identified. These include: assessment of the distance from the lower edge of the mesh to the ureterovesical segment, and implant integrity - specifically the absence of twisting, fragmentation, or ruptures of the hyperechoic mesh line (in B-mode and 3D reconstruction). Postoperative follow-up intervals for patients were proposed, including re-examination at one week, one month, and six months after treatment.</p> <p><strong>Conclusions.</strong> Ultrasound criteria for the «normal» visualization of the postoperative state after PP have been established. The introduction of multiparametric ultrasound into the routine practice of postoperative monitoring of patients after laparoscopic PP will allow to improve the quality of dynamic control, timely detect subclinical complications and optimize patient management tactics.</p> <p>The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patients was obtained for conducting the studies.</p> <p>No conflict of interest was declared by the authors.</p> 2025-12-28T00:00:00+02:00 Copyright (c) 2025 Ukrainian Journal Health of Woman