Prospects of using sFlt-1, PlGF as biomarkers of superimposed preeclampsia
DOI:
https://doi.org/10.15574/HW.2022.162.28Keywords:
сhronic hypertension, pregnancy, biomarkers, preeclampsia, superimposed preeclampsia, angiogenic factors, sFlt, PlGF, sFlt/PlGFAbstract
Chronic hypertension during pregnancy has recently shown a significant increase, which is most likely due to the growth in the number of first pregnancies in women of late reproductive age, with chronic hypertension, obesity and other extragenital diseases, as well as an increase in the number of pregnancies as a result of in vitro fertilization. Preeclampsia complicates chronic hypertension in 20-40% of cases, more often associated with early onset (before 34 weeks) and leads to an increase in complications in the mother, fetus and newborn. Currently, there are no reliable biomarkers that make it possible to predict the development of superimposed preeclampsia, but their search is underway. In the general obstetric population, the use of PlGF and sFlt-1 tests has shown to be promising for predicting preeclampsia in women with singleton pregnancies. PlGF and sFlt-1 based tests have begun to appear in clinical guidelines in addition to regular clinical and laboratory testing. But data on the effectiveness of these tests for predicting preeclampsia in groups of pregnant women with chronic diseases, including those with chronic hypertension, is still being collected.
Purpose - to evaluate the prospects of using angiogenic factors as biomarkers of superimposed preeclampsia; search for publications in electronic databases (Medline, Embase) from the earliest to January 2023.
Conclusions. Changes in angiogenesis markers may indicate the start preeclampsia in pregnant women with chronic hypertension. The values of angiogenesis markers in pregnant women with preeclampsia on the background of chronic hypertension may differ from those in pregnant women with preeclampsia, but without concomitant diseases. In addition, abnormalities in values of angiogenic markers in pregnant women with chronic hypertension compared to normotensive pregnant women may occur without the addition of preeclampsia. The reason may be the effect of chronic hypertension on the development and functioning of the placenta or an altered response of the endothelium to angiogenesis factors.
No conflict of interests was declared by the authors.
References
Binder J, Palmrich P, Kalafat E, Pateisky P, Öztürk E, Mittelberger J, Khalil A. (2021). Prognostic Value of Angiogenic Markers in Pregnant Women with Chronic Hypertension. Journal of the American Heart Association. 10 (17): e020631. https://doi.org/10.1161/JAHA.120.020631; PMid:34459247 PMCid:PMC8649241
Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC. (2014, Apr). Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ. 15 (348): g2301. https://doi.org/10.1136/bmj.g2301; PMid:24735917 PMCid:PMC3988319
Brosens I, Pijnenborg R, Vercruysse L, Romero R. (2011). The «Great Obstetrical Syndromes» are associated with disorders of deep placentation. Am J Obstet Gynecol. 204: 193. https://doi.org/10.1016/j.ajog.2010.08.009; PMid:21094932 PMCid:PMC3369813
Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S. (2018, Jul). Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension. 72 (1): 24-43. https://doi.org/10.1161/HYPERTENSIONAHA.117.10803; PMid:29899139
Browne JC, Veall N. (1953). The maternal placental blood flow in normotensive and hypertensive women. J Obstet Gynaecol Br Emp. 60 (2): 141-147. https://doi.org/10.1111/j.1471-0528.1953.tb07668.x; PMid:13053276
Costa RA, Hoshida MS, Alves EA, Zugaib M, Francisco RP. (2016, May). Preeclampsia and superimposed preeclampsia: The same disease? The role of angiogenic biomarkers. Hypertens Pregnancy. 35 (2): 139-149. Epub 2016 Mar 1. https://doi.org/10.3109/10641955.2015.1115063; PMid:26930132
Danielli M, Thomas RC, Gillies CL, Hu J, Khunti K, Bee TK. (2022). Blood biomarkers to predict the onset of preeclampsia: A systematic review and meta-analysis. Heliyon. 8 (11): e11226. https://doi.org/10.1016/j.heliyon.2022.e11226; PMid:36387521 PMCid:PMC9649987
Dommisse J, Tiltman AJ. (1992). Placental bed biopsies in placental abruption. BrJObstetGynaecol. 99 (8): 651-654. https://doi.org/10.1111/j.1471-0528.1992.tb13848.x; PMid:1390469
Duckitt K, Harrington D. (2005). Risk factors for preeclampsia at antenatal booking: systematic review of controlled studies. BMJ. 330: 565. https://doi.org/10.1136/bmj.38380.674340.E0; PMid:15743856 PMCid:PMC554027
Dwyer BK, Krieg S, Balise R, Carroll IR, Chueh J, Nayak N, Druzin M. (2010). Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 23 (7): 705-711. https://doi.org/10.3109/14767050903258753; PMid:19895348
Govseev DA. (2016). Tactics of treatment-and-prophylactic actions at women with repeated preeclampsia. Health of woman. 4 (110): 63-66.
Hernández-Pacheco JA, Rosales-Zamudio CI, Borboa-Olivares H, Espejel-Núñez A, Parra-Hernández S, Estrada-Gutiérrez G. (2020, Jul). The sFlt-1/PlGF ratio as a triage tool to identify superimposed preeclampsia in women with chronic hypertension in emergency rooms. Pregnancy Hypertens. 21: 38-42. Epub 2020 Apr 28. https://doi.org/10.1016/j.preghy.2020.04.014; PMid:32388017
Kaufmann P, Black S, Huppertz B. (2003). Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 69: 1. https://doi.org/10.1095/biolreprod.102.014977; PMid:12620937
Khong TY, De Wolf F, Robertson WB, Brosens I. (1986). Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 93 (10): 1049-1059. https://doi.org/10.1111/j.1471-0528.1986.tb07830.x; PMid:3790464
Kim YM, Bujold E, Chaiworapongsa T et al. (2003). Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 189 (4): 1063-1069. https://doi.org/10.1067/S0002-9378(03)00838-X; PMid:14586356
Kim YM, Chaiworapongsa T, Gomez R et al. (2002). Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol. 187 (5): 1137-1142. https://doi.org/10.1067/mob.2002.127720; PMid:12439491
Labarrere CA, DiCarlo HL, Bammerlin E et al. (2017). Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta. Am J Obstet Gynecol. 216 (3): 287, e281-287, e216. https://doi.org/10.1016/j.ajog.2016.12.029; PMid:28034657 PMCid:PMC5881902
Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF et al. (2004, Feb 12). Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 350 (7): 672-683. Epub 2004 Feb 5. https://doi.org/10.1056/NEJMoa031884; PMid:14764923
Maynard S, Epstein FH, Karumanchi SA. (2008). Preeclampsia and angiogenic imbalance. Annu Rev Med. 59: 61. https://doi.org/10.1146/annurev.med.59.110106.214058; PMid:17937587
Maynard SE, Karumanchi SA. (2011). Angiogenic factors and preeclampsia. Semin Nephrol. 31: 33. https://doi.org/10.1016/j.semnephrol.2010.10.004; PMid:21266263 PMCid:PMC3063446
Tanner MS, de Guingand D, Reddy M, Rowson S, Rolnik DL, Davey M-A, Mol BW, Wallace EM, Da Silva Costa F, Palmer KR. (2022). The effect of comorbidities on the sFLT-1: PlGF ratio in preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. Elsevier. https://doi.org/10.1016/j.preghy.2022.06.008; PMid:35843203
Molina-Pérez CJ, Nolasco-Leaños AG, Carrillo-Juárez RI, Leaños-Miranda A. (2022, Jul). Clinical usefulness of angiogenic factors in women with chronic kidney disease and suspected superimposed preeclampsia. J Nephrol. 35 (6): 1699-1708. Epub 2022 Mar 30. https://doi.org/10.1007/s40620-022-01299-9; PMid:35353367
Mosher R, Goldstein DP, Berkowitz R, Bernstein M, Genest DR. (1998). Complete hydatidiform mole. Comparison of clinicopathologic features, current and past. The Journal of reproductive medicine. 43 (1): 21-27.
Mosimann B, Amylidi-Mohr SK, Surbek D, Raio L. (2020). First trimester screening for preeclampsia - a systematic review. Hypertension in pregnancy. 39 (1): 1-11. https://doi.org/10.1080/10641955.2019.1682009; PMid:31670986
Murphy DJ, Stirrat GM. (2000). Mortality and morbidity associated with early-onset preeclampsia. Hypertens. Pregnancy. 19 (2): 221-231. https://doi.org/10.1081/PRG-100100138; PMid:10877990
Mustafa R et al. (2012). A comprehensive review of hypertension in pregnancy. J. Pregnancy. 2012: 105918. https://doi.org/10.1155/2012/105918; PMid:22685661 PMCid:PMC3366228
NICE. (2022). PLGF-based testing to help diagnose suspected preterm preeclampsia. URL: https://www.nice.org.uk/guidance/dg49.
Perni U, Sison C, Sharma V, Helseth G, Hawfield A, Suthanthiran M, August P. (2012, Mar). Angiogenic factors in superimposed preeclampsia: a longitudinal study of women with chronic hypertension during pregnancy. Hypertension. 59 (3): 740-746. Epub 2012 Feb 6. https://doi.org/10.1161/HYPERTENSIONAHA.111.181735; PMid:22311907
Pijnenborg R, Vercruysse L, Hanssens M. (2006). The uterine spiral arteries in human pregnancy: facts and controversies. Placenta. 27: 939. https://doi.org/10.1016/j.placenta.2005.12.006; PMid:16490251
Rich-Edwards JW, Ness RB, Roberts JM. (2014). Epidemiology of pregnancy-induced hypertension. In: Chesley's Hypertensive Disorders in Pregnancy, Taylor R, Roberts J, Cunningham F, Lindheimer M (Eds). Academic Press/Elsevier: 37. https://doi.org/10.1016/B978-0-12-407866-6.00003-1; PMid:24639442
Sagol S, Ozkinay E, Oztekin K, Ozdemir N. (1999). The comparison of uterine artery Doppler velocimetry with the histopathology of the placental bed. Aust N Z J Obstet Gynaecol. 39 (3): 324-329. https://doi.org/10.1111/j.1479-828X.1999.tb03407.x; PMid:10554944
Sibai B, Dekker G, Kupferminc M. (2005). Preeclampsia. Lancet. 365 (9461): 785-799. https://doi.org/10.1016/S0140-6736(05)71003-5
Skjaerven R, Wilcox AJ, Lie RT. (2002). The interval between pregnancies and the risk of preeclampsia. N Engl J Med. 346: 33. https://doi.org/10.1056/NEJMoa011379; PMid:11778000
Staff AC, Fjeldstad HE, Fosheim IK, Moe K, Turowski G, Johnsen GM, Alnaes-Katjavivi P, Sugulle M. (2022, Feb). Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. Am J Obstet Gynecol. 226 (2S): S895-S906. Epub 2020 Sep 21. https://doi.org/10.1016/j.ajog.2020.09.026; PMid:32971013
Stepan H, Faber R. (2006). Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops. N Engl J Med. 354: 1857. https://doi.org/10.1056/NEJMc052721; PMid:16641410
Voigt HJ, Becker V. (1992). Doppler flow measurements and histomorphology of the placental bed in uteroplacental insufficiency. J Perinat Med. 20 (2): 139-147. https://doi.org/10.1515/jpme.1992.20.2.139; PMid:1501057
Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M et al. (2016). Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia N. Engl. J. Med. 374 (1): 13-22. https://doi.org/10.1056/NEJMoa1414838; PMid:26735990
Bartsch E, Medcalf KE, Park AL, Ray JG. (2016, Apr 19). High Risk of Preeclampsia Identification Group. Clinical risk factors for preeclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ. 353: i1753. https://doi.org/10.1136/bmj.i1753; PMid:27094586 PMCid:PMC4837230
ACOG. (2019, Jan). Practice Bulletin No. 203: Chronic Hypertension in Pregnancy. Obstetrics & Gynecology. 133 (1): pe26-e50. https://doi.org/10.1097/AOG.0000000000003020; PMid:30575676
Romero R. (2020, Dec). Giants in Obstetrics and Gynecology Series: a profile of Ivo Brosens, MD, PhD, FRCOG (ae). Am J Obstet Gynecol. 223 (6): 809-819.e2. https://doi.org/10.1016/j.ajog.2020.09.008; PMid:33243413 PMCid:PMC8500677
Binder J, Kalafat E, Palmrich P, Pateisky P, Khalil A. (2022, Feb). Should angiogenic markers be included in diagnostic criteria of superimposed preeclampsia in women with chronic hypertension? Ultrasound Obstet Gynecol. 59 (2): 192-201. https://doi.org/10.1002/uog.23711; PMid:34165863
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Ukrainian Journal Health of Woman
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The policy of the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC).
Authors transfer the copyright to the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public.
Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited.
The use of published materials for commercial purposes is strongly prohibited.
