Structural changes and changes in the hormone-producing function of the thyroid gland during pregnancy in the natural cycle and with the use of additional reproductive technologies


  • O.O. Kyrylchuk Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine



thyroid dysfunction, thyroid hormones, pregnancy, assisted reproductive technologies


Purpose - to evaluate changes in thyroid function that occur during normal pregnancy and in the use of assisted reproductive technologies, various disorders with their consequences for the mother and fetus, laboratory diagnosis and the best ways to treat these conditions.

Common abnormalities of thyroid function, such as hypothyroidism, thyrotoxicosis and benign thyroid neoplasms, which disrupt menstrual cycles and female fertility, are considered, which, in turn, directly affect the course of pregnancy, and can lead to pregnancy termination, placental abruption, pre-eclampsia, preterm labor, neonatal morbidity, including reduced fetal neurological development. It has been suggested that the harmful effects of thyroid dysfunction may also extend not only to pregnancy and childbirth, but also affect the neuro-intellectual development of a child at an early age. Early diagnosis of thyroid dysfunction in pregnant women and treatment of thyroid dysfunction during pregnancy is an important and cost-effective aspect aimed at avoiding the occurrence of secondary complications in both the fetus and the mother caused by thyroid dysfunction.

No conflict of interests was declared by the authors.


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