Malformations of embryos and fetuses: world experience
DOI:
https://doi.org/10.15574/HW.2023.166.44Keywords:
termination of pregnancy for medical reasons, malformations of the embryo and fetusAbstract
Purpose - to investigate the causes, prevalence, variability and diagnosis of abortion for medical reasons in different countries of the world over the last 5 years according to scientific literature sources.
The article presents the analyzed literary data for different countries of the world, regarding the prevalence, detectability, variability, possible identified causes and consequences of abnormalities in the development of embryos and fetuses. According to the analyzed data of many literary sources, chromosomal abnormalities are the most frequent cause of sporadic miscarriages, which are found in 50-70% of first-trimester miscarriages and in 5-10% of all pregnancies in the world. The number of newborns with developmental disabilities in the world ranges from 2% to 8% and depends on the state of social development of the country. Moreover, in the countries of Europe and the USA, chromosomal abnormalities are found in the first place (56.2-52.6%), in the second place - anomalies of the central nervous system (11.8-13.4%), while in the countries of South Africa, in the first place on at this stage, anomalies of the musculoskeletal system appear (39%). In Asian countries, pathologies of the cardiovascular system are most often detected among all pathologies of embryo development (30.7%). Methods of diagnosis, prevention, treatment and termination of pregnancy are the same for all continents, but the problem is their availability in different countries.
No conflict of interests was declared by the author.
References
Abolhassani N, Winterfeld U, Kaplan YC, Jaques C, Minder Wyssmann B, Del Giovane C, Panchaud A. (2023, Jan). Major malformations risk following early pregnancy exposure to metformin: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. 11 (1): e002919. https://doi.org/10.1136/bmjdrc-2022-002919; PMid:36720508 PMCid:PMC9890805
Akinmoladun JA, Famosaya ID, Ogbole GI. (2022, Jan 24). Pattern and distribution of prenatally diagnosed congenital anomalies among high risk pregnant women in Ibadan, South Western Nigeria. Pan Afr Med J. 41: 66. https://doi.org/10.11604/pamj.2022.41.66.28874; PMid:35371376 PMCid:PMC8933448
American College of Obstetricians and Gynecologists' Committee on Health Care for Underserved Women, American College of Obstetricians and Gynecologists' Abortion Access and Training Expert Work Group. (2020, Dec). Increasing Access to Abortion: ACOG Committee Opinion. Number 815. Obstet Gynecol. 136 (6): e107-e115. https://doi.org/10.1097/AOG.0000000000004176; PMid:33214531
Bianchi DW, Chudova D, Sehnert AJ, Bhatt S, Murray K, Prosen TL et al. (2015, Jul 14). Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies. JAMA. 314 (2): 162-169. https://doi.org/10.1001/jama.2015.7120; PMid:26168314
Bosiak YuV. (2019). Pohliad reproduktolohiv na abort. Info Alternatyva. On-lain zhurnal. URL: https://alternatyva.clinic/magazine/poglyad-reproduktologiv-na-abort/.
Çaylan N, Yalçin SS, Tezel B, Aydin Ş, Üner O, Kara F. (2022, Apr 19). Evaluation of neural tube defects from 2014 to 2019 in Turkey. BMC Pregnancy Childbirth. 22 (1): 340. https://doi.org/10.1186/s12884-022-04678-z; PMid:35439969 PMCid:PMC9020109
Chen Y, Chen Y, Ning W, Zhang W, Li L, Wang X, Yin Y, Zhang H. (2022, Aug 10). Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18. Sci Rep. 12 (1): 13605. https://doi.org/10.1038/s41598-022-16807-x; PMid:35948592 PMCid:PMC9365830
Daum H, Ben David A, Nadjari M, Zenvirt S, Helman S, Yanai N et al. (2019, May). Role of late amniocentesis in the era of modern genomic technologies. Ultrasound Obstet Gynecol. 53 (5): 676-685. Epub 2019 Apr 12. https://doi.org/10.1002/uog.20113; PMid:30155922
Edling A, Lindström L, Bergman E. (2021, Dec). Second trimester induced abortions due to fetal anomalies-a population-based study of diagnoses, examinations and clinical management. Acta Obstet Gynecol Scand. 100 (12): 2202-2208. Epub 2021 Jul 23. https://doi.org/10.1111/aogs.14230; PMid:34244992
Fabre C, Pauly V, Baumstarck K, Etchecopar-Etchart D, Orleans V, Llorca PM et al. (2021, Sep 7). Pregnancy, delivery and neonatal complications in women with schizophrenia: a national population-based cohort study. Lancet Reg Health Eur. 10: 100209. https://doi.org/10.1016/j.lanepe.2021.100209; PMid:34806069 PMCid:PMC8589714
Goldenberg RL, Saleem S, Goudar SS, Silver RM, Tikmani SS, Guruprasad G et al. (2021, Oct). Preventable stillbirths in India and Pakistan: a prospective, observational study. BJOG. 128 (11): 1762-1773. Epub 2021 Jul 19. https://doi.org/10.1111/1471-0528.16820; PMid:34173998
Heaney S, Tomlinson M, Aventin Á. (2022, May 26). Termination of pregnancy for fetal anomaly: a systematic review of the healthcare experiences and needs of parents. BMC Pregnancy Childbirth. 22 (1): 441. https://doi.org/10.1186/s12884-022-04770-4; PMid:35619067 PMCid:PMC9137204
Heaney S, Tomlinson M, Aventin Á. (2022, May 26). Termination of pregnancy for fetal anomaly: a systematic review of the healthcare experiences and needs of parents. BMC Pregnancy Childbirth. 22 (1): 441. https://doi.org/10.1186/s12884-022-04770-4; PMid:35619067 PMCid:PMC9137204
Hewitt L, Dahlen HG, Hartz DL, Dadich A. (2021, Jul). Leadership and management in midwifery-led continuity of care models: A thematic and lexical analysis of a scoping review. Midwifery. 98: 102986. Epub 2021 Mar 11. https://doi.org/10.1016/j.midw.2021.102986; PMid:33774389
Hromova AM, Liakhovska TIu, Ketova OM, Nesterenko LA, Martynenko VB. (2019). Rol infektsii pry antenatalnykh vtratakh ploda u vahitnykh zhinok. Visnyk problem biolohii i medytsyny. 2 (2): 97-101. https://doi.org/10.29254/2077-4214-2019-2-2-151-97-101
Kalla A, Loucif L, Yahia M. (2021). Prevention of congenital malformations for pregnant women: A predictive model based on a study in eastern Algeria's population. Journal of Biological Research: 94. https://doi.org/10.4081/jbr.2021.9394
Kazakov VI, Bozhkov VM, Linde VA, Repina MA, Mikhaĭlov VM. (1995). Extracellular DNA in the blood of pregnant women. Tsitologiia. 37 (3): 232-236. PMID: 8553462.
Kuppusamy P, Prusty RK, Chaaithanya IK, Gajbhiye RK, Sachdeva G. (2023, Mar 8). Pregnancy outcomes among Indian women: increased prevalence of miscarriage and stillbirth during 2015-2021. BMC Pregnancy Childbirth. 23 (1): 150. https://doi.org/10.1186/s12884-023-05470-3; PMid:36890450 PMCid:PMC9992916
Ma Y, Liu X, Shi G, Liu Y, Zhou S, Hou W, Xu Y. (2021, Mar). Storage Time of Cryopreserved Embryos and Pregnancy Outcomes: A Dose-Response Meta-Analysis. Geburtshilfe Frauenheilkd. 81 (3): 311-320. Epub 2021 Mar 5. https://doi.org/10.1055/a-1326-1830; PMid:33692592 PMCid:PMC7938942
Maurice P, Letourneau A, Benachi A, Jouannic JM. (2019, Dec). Feticide in second- and third-trimester termination of pregnancy for fetal anomalies: Results of a national survey. Prenat Diagn. 39 (13): 1269-1272. Epub 2019 Nov 14. https://doi.org/10.1002/pd.5594; PMid:31671210
McCurry J. (2023, May 13). Japan approves abortion pill. Lancet. 401 (10388): 1558. https://doi.org/10.1016/S0140-6736(23)00955-8; PMid:37182522
Power S, O'Donoghue K, Meaney S. (2021, Apr). Experiences of Volunteers Supporting Parents Following a Fatal Fetal Anomaly Diagnosis. Qual Health Res. 31 (5): 835-846. Epub 2021 Jan 29. https://doi.org/10.1177/1049732320987834; PMid:33511913
Sainz JA, Torres MR, Peral I, Granell R, Vargas M, Carrasco P et al. (2020, Jul). Clinical and Economic Evaluation after Adopting Contingent Cell-Free DNA Screening for Fetal Trisomies in South Spain. Fetal Diagn Ther. 13: 1-8. Epub ahead of print. https://doi.org/10.1159/000508306; PMid:32659771
Suter SM. (2023, Jan 29). Why reason-based abortion bans are not a remedy against eugenics: an empirical study. J Law Biosci. 10 (1): lsac033. https://doi.org/10.1093/jlb/lsac033; PMid:36726964 PMCid:PMC9885976
Tafuri SM, Lui F. (2023, Jan). Embryology, Anencephaly. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID: 31424828.
Verma RP. (2021, Sep 28). Evaluation and Risk Assessment of Congenital Anomalies in Neonates. Children (Basel). 8 (10): 862. https://doi.org/10.3390/children8100862; PMid:34682127 PMCid:PMC8534483
Wang Z, Brauer R, Man KKC, Alfageh B, Mongkhon P, Wong ICK. (2021, Nov). Prenatal exposure to antipsychotic agents and the risk of congenital malformations in children: A systematic review and meta-analysis. Br J Clin Pharmacol. 87 (11): 4101-4123. Epub 2021 May 4. https://doi.org/10.1111/bcp.14839; PMid:33772841
Wei X, Ma W, Gu H, Liu D, Luo W, Bai Y et al. (2020, Jul 13). Transamniotic mesenchymal stem cell therapy for neural tube defects preserves neural function through lesion-specific engraftment and regeneration. Cell Death Dis. 11 (7): 523. https://doi.org/10.1038/s41419-020-2734-3; PMid:32655141 PMCid:PMC7354991
WHO OON. (2022). Hlobalnyi plan dii shchodo zdorov'ia ditei ta vplyv seredovyshcha, shcho yikh otochuie.
WHO. (2019). Newborns: Reducing Mortality. Who.int. URL: https://www.who.int/news-room/fact-sheets/detail/newborns-reducing-mortality.
WHO. (2020). Every Newborn: an action plan to end preventable deaths. URL: http://www.who.int/maternal_child_adolescent/topics/newborn/enap_consultation/en/.
Zhang M, Su Y, Sun YP. (2023, Mar 30). Gender bias in fetal malformations: A cross-sectional study in Asian populations. Front Endocrinol (Lausanne). 14: 1146689. https://doi.org/10.3389/fendo.2023.1146689; PMid:37065765 PMCid:PMC10101566
Zhang Q, Zhang ZC, He XY, Liu ZM, Wei GH, Liu X. (2022, Oct 3). Maternal smoking during pregnancy and the risk of congenital urogenital malformations: A systematic review and meta-analysis. Front Pediatr. 10: 973016. https://doi.org/10.3389/fped.2022.973016; PMid:36263151 PMCid:PMC9575702
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