Obstetric and perinatal pathology in women with a history of major obstetric syndromes
DOI:
https://doi.org/10.15574/HW.2023.167.15Keywords:
women, pregnancy, major obstetric syndromes, complications of pregnancy, complications of childbirth, condition of newbornsAbstract
Purpose - to determine the features of obstetric and perinatal pathology in women who had complications from the group of major obstetric syndromes (MOS) in the anamnesis during previous pregnancies.
Materials and methods. A prospective analysis of the course of pregnancy, childbirth and the condition of newborns was conducted in 120 pregnant women who had complications from the group of MOS in the anamnesis during previous pregnancies and received generally accepted diagnostic and treatment-prophylactic measures during this pregnancy (during 2019-2022).
Statistical processing of research results was performed using the standard programs Microsoft Excel 5.0 and Statistica 6.0.
Results. Peculiarities of the course of pregnancy and childbirth in women with a history of MOS are characterized by a high frequency of the threat of premature birth - 32.5% of cases, which determines the high frequency of perinatal pathology. In addition, it is possible to note the high frequency of premature births - 10.8% of cases. Attention is drawn to the stable high rates of the following complications of the III trimester of pregnancy: gestational anemia in 29.2% of cases; preeclampsia 13.3% of cases; placental insufficiency with growth retardation syndrome in 14.2% of cases; and violation of microbiocinosis of the genital tract in 24.2% of cases; without a tendency to decrease the frequency of these complications over the years. The consequence of these complications is an increase in the frequency of cesarean sections to 30.1% of cases.
Conclusions. The identified features of obstetric and perinatal pathology in pregnant women who had complications from the MOS group during previous pregnancies can serve as markers for predicting the risk of developing complications from the mother and the fetus in these pregnant women. In our opinion, further analysis of functional, instrumental and laboratory indicators in these women can provide an opportunity to identify the most informative prognostic criteria regarding the development of MOS, and will allow the development of an effective method of predicting obstetric and perinatal complications in these women.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Women's informed consent was obtained for the study.
No conflict of interests was declared by the author.
References
Abalos E, Cuesta C, Carroli G, Qureshi Z, Widmer M, Vogel J, Souza J. (2014). Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the World Health Organization multicountry survey on maternal and newborn health. BJOG : an international journal of obstetrics and gynecology. 121: 14-24. https://doi.org/10.1111/1471-0528.12629; PMid:24641531
Boutin A, Demers S, Gasse C, Giguère Y, Tétu A, Laforest G, Bujold E. (2019). First-trimester placental growth factor for the prediction of preeclampsia in nulliparous women: the great obstetrical syndromes cohort study. Fetal Diagnosis and Therapy. 45 (2): 69-75. https://doi.org/10.1159/000487301; PMid:30304731
Boutin A, Gasse C, Demers S, Giguère Y, Tétu A, Bujold E. (2018). Maternal characteristics for the prediction of preeclampsia in nulliparous women: the great obstetrical syndromes (GOS) study. Journal of Obstetrics and Gynaecology Canada. 40 (5): 572-578. https://doi.org/10.1016/j.jogc.2017.07.025; PMid:29079078
Boutin A, Gasse C, Guerby P, Giguère Y, Tétu A, Bujold E. (2021). First-trimester preterm preeclampsia screening in nulliparous women: the great obstetrical syndrome (GOS) study. Journal of Obstetrics and Gynaecology Canada. 43 (1): 43-49. https://doi.org/10.1016/j.jogc.2020.06.011; PMid:32917539
Boutin A, Guerby P, Gasse C, Tapp S, Bujold E. (2021). Pregnancy outcomes in nulliparous women with positive first-trimester preterm preeclampsia screening test: the Great Obstetrical Syndromes cohort study. American journal of obstetrics and gynecology. 224 (2): 204-e1. https://doi.org/10.1016/j.ajog.2020.08.008; PMid:32777265
Brosens I, Pijnenborg R, Vercruysse L, Romero R. (2011). The «Great Obstetrical Syndromes» are associated with disorders of deep placentation. Am J Obstet Gynec. 204 (3): 193-201. https://doi.org/10.1016/j.ajog.2010.08.009; PMid:21094932 PMCid:PMC3369813
Demers S, Boutin A, Gasse C, Drouin O, Girard M, Bujold E. (2019). First-trimester uterine artery Doppler for the prediction of preeclampsia in nulliparous women: the great obstetrical syndrome study. American journal of perinatology. 36 (9): 930-935. https://doi.org/10.1055/s-0038-1675209; PMid:30414599
Di Renzo GC, Cabero RL, Facchinetti F, Helmer H, Hubinont C, Jacobsson B et al. (2017). Preterm labor and birth management: recommendations from the European Association of Perinatal Medicine. The Journal of Maternal-Fetal & Neonatal Medicine. 30 (17): 2011-2030. https://doi.org/10.1080/14767058.2017.1323860; PMid:28482713
Di Renzo GC, Tosto V, Giardina I. (2018). The biological basis and prevention of preterm birth. Best Practice & Research Clinical Obstetrics & Gynaecology. 52: 13-22. https://doi.org/10.1016/j.bpobgyn.2018.01.022; PMid:29703554
Di Renzo GC. (2009). The great obstetrical syndromes. The Journal of Maternal-Fetal & Neonatal Medicine. 22; 8: 633-635. https://doi.org/10.1080/14767050902866804; PMid:19736613
Docheva N, Romero R, Chaemsaithong P, Tarca AL, Bhatti G, Pacora P et al. (2019). The profiles of soluble adhesion molecules in the "great obstetrical syndromes". The Journal of Maternal-Fetal & Neonatal Medicine. 32 (13): 2113-2136. https://doi.org/10.1080/14767058.2018.1427058; PMid:29320948 PMCid:PMC6070437
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gotsch F. (2022). Preeclampsia and eclampsia: the conceptual evolution of a syndrome. American journal of obstetrics and gynecology. 226 (2): S786-S803. https://doi.org/10.1016/j.ajog.2021.12.001; PMid:35177220 PMCid:PMC8941666
Frolova NA, Tezikov YV, Lipatov IS. (2021). Justification of the choice of diosmin vasoprotective as a preventive agent of pre-eclampsia. Reproductive health of woman. 1 (46): 40-43. https://doi.org/10.30841/2708-8731.1.2021.229710
Ivo B, Puttemans P, Benagiano G. (2019). Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes. American journal of obstetrics and gynecology. 221; 5: 437-456. https://doi.org/10.1016/j.ajog.2019.05.044; PMid:31163132
Jung E, Romero R, Yeo L, Gomez-Lopez N, Chaemsaithong P, Jaovisidha A et al. (2022). The etiology of preeclampsia. American journal of obstetrics and gynecology. 226 (2): S844-S866. https://doi.org/10.1016/j.ajog.2021.11.1356; PMid:35177222 PMCid:PMC8988238
Miller D et al. (2022). Cellular immune responses in the pathophysiology of preeclampsia. Journal of Leukocyte Biology. 111; 1: 237-260. https://doi.org/10.1002/JLB.5RU1120-787RR; PMid:33847419 PMCid:PMC8511357
Mintser AP. (2018). Statisticheskie metodyi issledovaniya v klinicheskoy meditsine. Prakticheskaya meditsina. 3: 41-45.
Poon LC et al. (2019). The International Federation of Gynecology and Obstetrics (FIGO) initiative on preeclampsia (PE): a pragmatic guide for first trimester screening and prevention. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 145 (1): 1.
Romero R et al. (2022). Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology. American Journal of Obstetrics and Gynecology. 227; 4: 615-e1. https://doi.org/10.1016/j.ajog.2022.04.015; PMid:36180175 PMCid:PMC9525890
Romero R, Kusanovic JP, Kim ChJ. (2010). Placental bed disorders in the genesis of the great obstetrical syndromes. Cambridge University Press: 271-289. https://doi.org/10.1017/CBO9780511750847.025; PMid:20036322
Scott H, Danel I. (2016). Accountability for improving maternal and newborn health. Best Practice & Research Clinical Obstetrics & Gynaecology. 36: 45-56. https://doi.org/10.1016/j.bpobgyn.2016.05.009; PMid:27473405
Simcha Y, Cohen SM, Goldman-Wohl D. (2022). An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array. American journal of obstetrics and gynecology. 226; 2: S963-S972. https://doi.org/10.1016/j.ajog.2020.10.023; PMid:33712272
Staff AC et al. (2022). Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. American journal of obstetrics and gynecology. 226; 2: S895-S906. https://doi.org/10.1016/j.ajog.2020.09.026; PMid:32971013
Stevens DU, de Nobrega Teixeira JA, Spaanderman MEA, Bulten J, van Vugt JMG, Al-Nasiry S. (2020). Understanding decidual vasculopathy and the link to preeclampsia: a review. Placenta. 97: 95-100. https://doi.org/10.1016/j.placenta.2020.06.020; PMid:32792071
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