The effect of preventive therapy for placental dysfunction on uteroplacental blood flow in pregnant women with low-lying placenta
DOI:
https://doi.org/10.15574/HW.2025.6(186).3236Keywords:
placental dysfunction, low placentation, preventive therapy, uteroplacental blood flow, DopplerometryAbstract
The mother's health and the quality of placental formation in early pregnancy determine the course of gestation, fetal development, and neonatal prognosis. One of the key disorders that negatively affects these processes is placental dysfunction, in the development of which low chorionic attachment plays a special role, disrupting implantation and vascularization of the placenta.
Aim - to evaluate the effectiveness of a complex of preventive measures for the formation of uteroplacental blood flow in pregnant women with low chorionic localization in early pregnancy.
Materials and methods. A total of 119 pregnant women were observed: 64 patients received preventive therapy (micronized progesterone, ginkgo biloba, folic acid, and magnesium) from early gestation and 55 patients were in the control group without preventive intervention. Doppler parameters of the right and left uterine arteries and spiral arteries were evaluated, as well as the morphofunctional characteristics of the chorion using three-dimensional VOCAL technology (chorion volume, vascularization index).
Results. In patients of the main group, there was a significant decrease in resistance indices in the uterine and spiral arteries, an increase in diastolic and mean blood flow velocities by 30-40%, an increase in chorionic volume (62.0±4.1 cm3 vs. 48.1±3.8 cm3) and its vascularization (vascularization index - 17.8±0.38 vs. 9.68±0.12) compared to the control group. The data indicate an improvement in the hemodynamics of the “mother-placenta-fetus” system and more effective formation of the fetoplacental complex.
Conclusions. Early application of the proposed complex of preventive measures in pregnant women with low-lying placenta contributes to the normalization of uteroplacental blood flow, improves chorionic vascularization, and reduces the risk of developing primary placental dysfunction, which provides favorable conditions for fetal development.
The study was performed in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from all patients.
The author declares no conflict of interest.
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