Clinical predictors of unsuccessful assisted reproductive technology attempts in women with chronic endometritis
DOI:
https://doi.org/10.15574/HW.2026.1(182).7277Keywords:
infertility, chronic endometritis, assisted reproductive technologies, hormonal status, ultrasound examinations of the pelvic organs, hysteroscopy, morphological studies of the endometriumAbstract
The relevance of the infertility problem determines the need to address issues related to improving diagnostic methods, increasing the effectiveness of treatment and prevention of infertility, as well as searching for prognostic criteria for the effectiveness of assisted reproductive technologies (ART) in chronic endometritis (CE).
Aim - to analyze the premorbid background (hormonal status, ultrasound and hysteroscopy data) in women with CE in infertility to identify clinical predictors of unsuccessful outcome of ART programs.
Materials and methods. A clinical statistical analysis of hormonal status (luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), estradiol (E2), testosterone (T), cortisol (K), thyroid-stimulating hormone (TSH), free thyroxine (T4b), dehydroepiandrosterone (DHEA-S)), ultrasound and hysteroscopy data in 128 women with tubal factor infertility participating in ART programs. The main group (OG) - 63 women with infertility on the background of HE, the comparison group (CG) - infertility without HE, consisted of 65 people, the control group (CG) - 45 healthy fertile women.
Results. Indicators of FSH, LH, prolactin, E2, TSH and T4v were comparable in all groups and indicated the absence of thyroid pathology. The presence of a heterogeneous endometrial contour in OG was significantly higher by 5.1 times, increased endometrial echogenicity by 5.8 times, and expansion of the uterine cavity by 13.7 times. The OG had the maximum number of women with a thinned, weakened mucous membrane - 22 (34.9%) and the presence of intrauterine synechiae - 10 (15.9%), which also affects the effectiveness of ART programs.
Conclusions. Clinical predictors of unsuccessful ART programs in women with infertility due to ectopic pregnancy may be reliable features of endometrial pathology.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The informed consent of the patients was obtained for conducting the studies.
The authors declare no conflict of interest.
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