Post-COVID syndrome and its effects on a woman's body
DOI:
https://doi.org/10.15574/HW.2026.1(182).117124Keywords:
post-COVID syndrome, COVID-19, immune disorders, hormonal imbalance, reproductive health, female body, menstrual cycle disorders, psychoemotional disorders, rehabilitationAbstract
The article is devoted to the study of post-COVID syndrome (PCS) as a current medical and social problem and its consequences for the human body, in particular, the female body. Based on the analysis of modern scientific sources, the main clinical manifestations, pathogenetic mechanisms, and the most common symptoms after COVID-19 have been considered. It has been established that PCS is a multisystem condition with long-term manifestations that significantly affect physical, psychoemotional and reproductive health, reduce the quality of life and working capacity of patients.
The aim is to generalize and analyze modern scientific data on clinical manifestations, pathogenetic mechanisms, and long-term consequences of PCS, as well as to assess its impact on the functional state and health of the female body, taking into account physical, psychoemotional, and reproductive aspects.
As a result of the analysis of scientific publications, it was established that PCS is characterized by multisystem damage to the body with a predominance of asthenic, neurological, cardiorespiratory, and psychoemotional manifestations. In women, PCS is more often accompanied by chronic fatigue, sleep disorders, anxiety and depression, autonomic dysfunction and decreased performance. A connection has been found between the development of PCS and prolonged immune activation, endothelial dysfunction and hormonal imbalance, which can lead to menstrual cycle disorders, deterioration of reproductive health and exacerbation of concomitant somatic and gynecological pathologies. The data obtained indicate a significant negative impact of PCS on the quality of life of women and their social activity.
Conclusion. PCS is a complex multifactorial condition with long-term consequences for the female body, which requires a comprehensive, interdisciplinary approach to diagnosis, treatment, and rehabilitation. Taking into account the gender characteristics of the course of PCS is a necessary condition for increasing the effectiveness of medical care. Further research should be aimed at clarifying the mechanisms of development of post-COVID complications in women and developing standardized patient management protocols to improve long-term clinical outcomes and quality of life.
The authors declare the absence of a conflict of interest.
References
Al-Aly Z, Xie Y, Bowe B. (2021). High-dimensional characterization of post-acute sequelae of COVID-19. Nature. 594(7862): 259-264. https://doi.org/10.1038/s41586-021-03553-9; PMid:33887749
Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. (2020). Persistent symptoms in patients after acute COVID-19. JAMA. 324(6): 603-605. https://doi.org/10.1001/jama.2020.12603; PMid:32644129 PMCid:PMC7349096
Crook H, Raza S, Nowell J, Young M, Edison P. (2021). Long COVID - mechanisms, risk factors, and management. BMJ. 374: n1648. https://doi.org/10.1136/bmj.n1648; PMid:34312178 PMCid:PMC10827472
Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y et al. (2021). Characterizing long COVID in an international cohort. EClinicalMedicine. 38: 101019. https://doi.org/10.1016/j.eclinm.2021.101019; PMid:34308300 PMCid:PMC8280690
Dennis A, Wamil M, Alberts J, Oben J, Cuthbertson DJ, Wootton D et al. (2021). Multiorgan impairment in low-risk individuals with long COVID. BMJ Open. 11(3): e048391. https://doi.org/10.1136/bmjopen-2020-048391; PMid:33785495 PMCid:PMC8727683
Ding T, Wang T, Zhang J, Cui P, Chen Z, Jiang J et al. (2021). Potential influence of menstrual status on female SARS-CoV-2 infection. Clin Infect Dis. 72(9): e240-e248. https://doi.org/10.1093/cid/ciaa1022; PMid:32697835 PMCid:PMC7454316
Fernández-de-Las-Peñas C, Martín-Guerrero JD, Pellicer-Valero ÓJ, Navarro-Pardo E, Gómez-Mayordomo V, Cuadrado ML et al. (2022). Female sex is a risk factor associated with long-term post-COVID related symptoms. J Clin Med. 11(7): 2001. https://doi.org/10.3390/jcm11072001; PMid:35407609 PMCid:PMC9000076
Huang C, Huang L, Wang Y, Li X, Ren L, Gu X et al. (2021). 6-month consequences of COVID-19 in patients discharged from hospital. Lancet. 397(10270): 220-232. https://doi.org/10.1016/S0140-6736(20)32656-8; PMid:33428867 PMCid:PMC7833295
Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A et al. (2021). More than 50 long-term effects of COVID-19: a systematic review. Sci Rep. 11: 16144. https://doi.org/10.1038/s41598-021-95565-8; PMid:34373540 PMCid:PMC8352980
Michelen M, Manoharan L, Elkheir N, Cheng V, Dagens A, Hastie C et al. (2021). Characterising long COVID: a living systematic review. BMJ Glob Health. 6(9): e005427. https://doi.org/10.1136/bmjgh-2021-005427; PMid:34580069 PMCid:PMC8478580
Nalbandian A, Sehgal K, Gupta A. (2023). Long COVID: pathophysiology and clinical approach. Annu Rev Med. 74: 365-386. https://doi.org/10.1146/annurev-med-043021-030635; PMid:35914765
Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS et al. (2021). Post-acute COVID-19 syndrome. Nat Med. 27(4): 601-615. https://doi.org/10.1038/s41591-021-01283-z; PMid:33753937 PMCid:PMC8893149
Ortona E, Buonsenso D, Carfi A, Malorni W. (2020). Long COVID: an estrogen-associated autoimmune disease? Front Immunol. 11: 1987. https://doi.org/10.3389/fimmu.2020.01987; PMid:33101267 PMCid:PMC7546816
Proal AD, VanElzakker MB. (2021). Long COVID or post-acute sequelae of COVID-19 (PASC): an overview. Front Microbiol. 12: 698169. https://doi.org/10.3389/fmicb.2021.698169; PMid:34248921 PMCid:PMC8260991
Raj SR, Arnold AC, Barboi A, Claydon VE, Limberg JK, Lucci VEM et al. (2021). Long-COVID postural tachycardia syndrome. Nat Rev Cardiol. 18(11): 701-703. https://doi.org/10.1038/s41569-021-00631-3; PMid:34686843 PMCid:PMC8532434
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC et al. (2021). Attributes and predictors of long COVID. Nat Med. 27(4): 626-631. https://doi.org/10.1038/s41591-021-01292-y; PMid:33692530 PMCid:PMC7611399
Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. (2021). 6-month neurological and psychiatric outcomes in COVID-19 survivors. Lancet Psychiatry. 8(5): 416-427. https://doi.org/10.1016/S2215-0366(21)00084-5; PMid:33836148 PMCid:PMC8023694
Tenforde MW, Kim SS, Lindsell CJ, Billig Rose E, Shapiro NI, Files DC et al. (2020). Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19. MMWR Morb Mortal Wkly Rep. 69(30): 993-998. https://doi.org/10.15585/mmwr.mm6930e1; PMid:32730238 PMCid:PMC7392393
Xiong Q, Xu M, Li J, Liu Y, Zhang J, Xu Y et al. (2021). Clinical sequelae of COVID-19 survivors. Clin Microbiol Infect. 27(1): 89-95. https://doi.org/10.1016/j.cmi.2020.12.023; PMid:33429027
Yong SJ. (2021). Persistent brainstem dysfunction in long COVID: a hypothesis. Neurosci Lett. 745: 135769. https://doi.org/10.1016/j.neulet.2021.135769; PMid:33636285
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